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Overexpression of Sirtuin 1 (Sirt1) upregulated the expression of inflammatory cytokines and downregulated the expression of p53. Cells were first transfected with empty pcDNA3.1 or pc-Sirt1, and then the mRNA level expressions of pro-inflammatory cytokines (A) and p53 (B) in transfected cells were determined by RT-PCR. * p<0.05; ** p<0.01.
