Table 1. Label free proteomic analysis.
| Protein name | p-value | Log 2 Fold Change | Change direction | Significance |
|---|---|---|---|---|
| SLC25A46 | Not Applicable | ∞ (only in WT) | extinguished | *** |
| Fusion/Fission | ||||
| OPA1 | 0.000639 | 0.81 | up | *** |
| MFN2 | 0.024845 | 0.43 | up | * |
| MFF | 0.000139 | 1.14 | up | *** |
| MICOS complex | ||||
| IMMT | 0.004325 | 0.65 | up | ** |
| CHCHD3 | 0.006141 | 0.56 | up | ** |
| CHCHD6 | 0.049151 | 0.55 | up | * |
| SAM | ||||
| SAMM50 | 0.003500 | 0.46 | up | ** |
| Porins | ||||
| VDAC1 | 0.012494 | 0.39 | up | * |
| VDAC2 | 0.017235 | 0.27 | up | * |
| Translocation complex | ||||
| TIMM22 | 0.000239 | 1.02 | up | *** |
| TIMM44 | 0.000352 | 1.02 | up | *** |
| TOMM22 | 0.001122 | 0.64 | up | ** |
| TOMM40 | 0.002626 | 0.51 | up | ** |
| TOMM70a | 0.021190 | 0.27 | up | * |
Up-regulated mitochondrial proteins in atc/atc mice compared to WT mice. Functional categories and selected proteins, p-value and average log2 fold differences (four biological and three technical replicas) have been calculated as described in Methods. Not Applicable: p-value due to absence of SLC25A46 protein in atc/atc mice.
∞, the difference is infinite due to lack of detection in one of the compared groups. Up, up-regulated in atc/atc mice.
*p<0.05,
**p<0.01, and
***p<0.001.