Table 2. Characteristics of patients aged 30 to 84 in the CPRD study cohort who were free from CVD at baseline.
Patients are stratified by first CVD event during the 10-year follow-up period.
| Risk Factor Variables | Units | CVD (n = 24,970) | No CVD (n = 353,286) | P-Value |
|---|---|---|---|---|
| Age* | years (SD) | 65.3 (11.1) | 57.6 (12.8) | < 0.001 |
| BMI+ | kg/m^2 (SD) | 27.9 (4.94) | 27.9 (5.21) | 0.323 |
| Systolic blood pressure* | mm HG (SD) | 141 (17.6) | 137 (17.2) | < 0.001 |
| Total cholesterol* | mmol/L (SD) | 5.60 (1.11) | 5.56 (1.06) | < 0.001 |
| HDL cholesterol* | mmol/L (SD) | 1.39 (0.41) | 1.46 (0.43) | < 0.001 |
| LDL cholesterol | mmol/L (SD) | 3.45 (0.91) | 3.40 (0.88) | < 0.001 |
| Triglycerides+ | mmol/L (SD) | 1.69 (0.85) | 1.57 (0.83) | < 0.001 |
| CRP+ | mg/L (SD) | 10.0 (13.7) | 8.37 (11.5) | < 0.001 |
| Serum fibrinogen+ | g/L (SD) | 3.86 (1.22) | 3.73 (1.33) | 0.129 |
| gamma GT+ | IU/L (SD) | 41.3 (33.7) | 39.3 (33.6) | < 0.001 |
| Serum creatinine+ | umol/L (SD) | 91.9 (17.3) | 87.6 (16.0) | < 0.001 |
| HbA1c+ | % (SD) | 7.26 (1.61) | 7.14 (1.64) | < 0.001 |
| FEV1+ | % (SD) | 66.2 (16.3) | 67.8 (16.9) | 0.007 |
| AST/ALT ratio+ | — (SD) | 1.04 (0.36) | 1.01 (0.35) | < 0.001 |
| Female* | % | 41.8 | 52.8 | < 0.001 |
| Smoking* | % | 23.4 | 20.5 | < 0.001 |
| Family history CHD < 60 years | % | 5.00 | 5.51 | < 0.001 |
| Ethnicitya: South Asian | % | 2.27 | 1.90 | 0.004 |
| Ethnicitya: Black/Afro-Caribbean | % | 0.66 | 1.20 | < 0.001 |
| Ethnicitya: Chinese/East Asian | % | 0.54 | 0.58 | 0.465 |
| Ethnicitya: Other/Mixed | % | 0.85 | 1.32 | < 0.001 |
| Ethnicitya: Unknown | % | 43.5 | 57.1 | < 0.001 |
| SESb: 2nd Townsend quintile | % | 15.8 | 16.0 | < 0.001 |
| SESb: 3rd Townsend quintile | % | 13.7 | 13.6 | < 0.001 |
| SESb: 4th Townsend quintile | % | 12.6 | 11.8 | < 0.001 |
| SESb: 5th Townsend quintile (most deprived) | % | 7.95 | 6.91 | < 0.001 |
| SESb: Unknown | % | 34.6 | 34.5 | < 0.001 |
| Hypertension | % | 31.8 | 25.2 | < 0.001 |
| Diabetes | % | 15.0 | 10.1 | < 0.001 |
| Blood pressure treatment* | % | 28.3 | 21.9 | < 0.001 |
| Rheumatoid arthritis | % | 1.55 | 0.91 | < 0.001 |
| Chronic kidney disease | % | 0.99 | 0.48 | < 0.001 |
| Atrial fibrillation | % | 4.64 | 2.20 | < 0.001 |
| COPD | % | 3.97 | 2.02 | < 0.001 |
| Severe mental illness | % | 0.34 | 0.32 | 0.563 |
| Anti-psychotic drug prescribed | % | 15.2 | 12.7 | < 0.001 |
| Oral corticosteroid prescribed | % | 13.2 | 9.55 | < 0.001 |
| Immunosuppressant prescribed | % | 13.3 | 9.70 | < 0.001 |
| BMI missing | % | 3.48 | 5.87 | < 0.001 |
| LDL cholesterol missing | % | 25.1 | 24.6 | 0.041 |
| Triglycerides missing | % | 11.7 | 12.3 | 0.004 |
| CRP missing | % | 88.5 | 89.9 | < 0.001 |
| Serum fibrinogen missing | % | 99.0 | 99.0 | 0.207 |
| gamma GT missing | % | 64.8 | 69.1 | < 0.001 |
| Serum creatinine missing | % | 16.1 | 21.5 | < 0.001 |
| HbA1c missing | % | 79.6 | 85.9 | < 0.001 |
| FEV1 missing | % | 96.3 | 97.7 | < 0.001 |
| AST/ALT ratio missing | % | 85.2 | 88.2 | < 0.001 |
*core risk factor for ACC/AHA 10-year CVD risk equations
+missing values present
areference category is White Caucasian
breference category is 1st Townsend quintile (most affluent)