Table 1.
The 26 miRNAs significantly aberrantly expressed in HCC tumor compared to nontumor tissues using the mean of all miRNAs as the normalizer
| miRNAs | Geometric mean in tumor tissue | Geometric mean in non-tumor tissue | Fold-change | P-value | FDR |
|---|---|---|---|---|---|
| miR-196b | 1.10E-01 | 7.30E-03 | 16.56 | 2.88E-05 | 1.41E-03 |
| miR-183 | 1.90E-02 | 1.40E-03 | 16.29 | 1.86E-04 | 4.47E-03 |
| miR-182 | 4.10E-02 | 3.20E-03 | 14.11 | 1.77E-05 | 1.41E-03 |
| miR-10b# | 8.10E-02 | 8.60E-03 | 10.13 | 1.41E-05 | 1.41E-03 |
| miR-1180 | 2.50E-02 | 9.10E-03 | 4.56 | 2.90E-04 | 6.55E-03 |
| miR-221 | 3.10E-01 | 7.40E-02 | 4.13 | 5.87E-04 | 1.00E-02 |
| miR-18a | 1.90E-01 | 5.70E-02 | 4.00 | 1.39E-04 | 3.58E-03 |
| miR-130b# | 1.10E-02 | 3.20E-03 | 3.97 | 7.69E-04 | 1.06E-02 |
| miR-222 | 1.81E+01 | 6.42E+00 | 2.81 | 6.48E-04 | 1.02E-02 |
| miR-339-3p | 1.70E-01 | 6.50E-02 | 2.62 | 1.08E-04 | 3.54E-03 |
| miR-21 | 1.30E+01 | 5.20E+00 | 2.49 | 9.27E-04 | 1.12E-02 |
| miR-324-5p | 8.30E-02 | 3.40E-02 | 2.47 | 6.11E-04 | 1.00E-02 |
| miR-550 | 3.30E-02 | 1.40E-02 | 2.38 | 3.87E-04 | 7.76E-03 |
| miR-362 | 1.10E-01 | 4.90E-02 | 2.30 | 7.96E-04 | 1.06E-02 |
| miR-148b | 6.60E-02 | 3.00E-02 | 2.28 | 8.78E-04 | 1.09E-02 |
| miR-106a | 5.19E+01 | 2.29E+01 | 2.27 | 8.20E-06 | 1.41E-03 |
| miR-93# | 1.30E+00 | 6.10E-01 | 2.14 | 8.28E-04 | 1.07E-02 |
| miR-139-5p | 4.70E-01 | 2.47E+00 | −5.26 | 3.13E-05 | 1.41E-03 |
| miR-144# | 4.60E-02 | 2.10E-01 | −5.00 | 5.78E-05 | 2.09E-03 |
| miR-214 | 5.20E-01 | 2.29E+00 | −4.35 | 7.09E-04 | 1.02E-02 |
| miR-486 | 1.90E-01 | 8.20E-01 | −4.35 | 5.10E-06 | 1.41E-03 |
| miR-199a-3p | 1.61E+00 | 5.95E+00 | −3.70 | 6.84E-04 | 1.02E-02 |
| miR-511 | 3.00E-02 | 1.10E-01 | −3.33 | 1.28E-04 | 3.54E-03 |
| miR-424 | 1.40E-02 | 2.70E-02 | −2.94 | 4.02E-05 | 1.61E-03 |
| miR-125b | 1.23E+00 | 2.74E+00 | −2.22 | 2.24E-05 | 1.41E-03 |
| miR-598 | 4.30E-02 | 8.50E-02 | −2.00 | 5.96E-04 | 1.00E-02 |
miRNA: microRNA; HCC: hepatocellular carcinoma; FDR: false discovery rate