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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Mol Cancer Res. 2017 Feb 16;15(4):361–370. doi: 10.1158/1541-7786.MCR-16-0436

Figure 3. Prostate cancer resource patches and dispersal corridors.

Figure 3

(A) Primary prostate tumor from prostate cancer patient radical prostatectomy. (a: lymphovascular vessel, b: nerve, c: intraductal carcinoma, d: stromal infiltration) (B) Prostate cancer resource patches: Colored regions represent patches within the primary tumor and depict spatial heterogeneity at single moment in time. Variations in color represent variations in patch characteristics (i.e. resource and predation risk). Importantly, though not depicted, patch geography and characteristics change over time. (C) Dispersal corridors including blood vessels (red and maroon), lymph vessels (green), and nerves (orange) intersect primary tumor patches and provide a route for long-distance dissemination out of the primary tumor habitat. (H&E; scale bar = 300 μm; image courtesy of Dr. Tamara Lotan, Johns Hopkins University)