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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Mol Cancer Res. 2017 Jan 13;15(4):418–428. doi: 10.1158/1541-7786.MCR-16-0366

Figure 1. 14-3-3σ contributes to cellular resistance to DNA-damaging drugs and IR.

Figure 1

(A) Western blot analysis of 14-3-3σ in stable MiaPaCa-2/Vec and MiaPaCa-2/σ and in BxPC-3/Scr and BxPC-3/Sh-σ cells. (B) MTT assay of survival against different therapeutic drugs. GEM, gemcitabine; MTX, mitoxantrone; DOX, doxorubicin. Relative resistance factor (REF)=IC50(MiaPaCa-2/σ)/IC50(MiaPaCa-2/Vec) or IC50(BxPC-3/Sh-σ)/IC50(BxPC-3/Scr). (C) Colony formation assay of survival against IR. (*p<0.05; **p<0.01; n=3).