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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Card Fail. 2016 Nov 24;23(4):314–324. doi: 10.1016/j.cardfail.2016.11.006

Figure 5.

Figure 5

Expression of TIMP-1, TIMP-2, TIMP-3, and TIMP-4 in adult and pediatric IDC LV normalized to age-matched NF controls. A. Expression of TIMP-1 in adult IDC LV normalized to NF controls. Significance was determined using unpaired Student’s t-test with Welch’s correction: p = 0.003. B. Expression of TIMP-1 in pediatric IDC LV normalized to age-matched NF controls. Mann-Whitney analysis was used to determine significance: p = 0.0001. C. Expression of TIMP-1 in pediatric failing IDC LV separated by presence of fibrosis. Significance was determined by one way ANOVA with Sidak’s multiple comparison test: NF v no fibrosis p = 0.02; NF v fibrosis p = 0.003. D. Expression of TIMP-2 in adult IDC LV normalized to NF controls. Significance was determined by unpaired Student’s t-test with Welch’s correction. E. TIMP-2 expression in pediatric IDC LV normalized to age-matched controls. Unpaired Student’s t-test with Welch’s correction determined there is a significant increase in TIMP-2 expression in pediatric IDC LV compared with age-matched NF controls: p <0.0001. F. Comparison of TIMP-2 expression in pediatric fibrotic and not fibrotic LV. One-way ANOVA with Sidak’s multiple comparison test demonstrated significant differences between the groups: NF v no fibrosis p = 0.03; NF v fibrosis p < 0.0001. G. Expression of TIMP-3 in adult IDC LVs normalized to NF controls. Significance was determined by an unpaired Student’s t-test with Welch’s correction: p = 0.025. H. TIMP-3 expression in pediatric IDC LV normalized to NF controls. Significance was determined by unpaired Student’s t-test with Welch’s correction. I. Comparison of TIMP-3 expression in pediatric fibrotic and non-fibrotic IDC hearts. There was no significant difference between the groups as assessed by one way ANOVA with Sidak’s multiple comparison test. J. Expression of TIMP-4 in adult IDC LVs normalized to NF controls. Significance was determined by an unpaired Student’s t-test with Welch’s correction: p = 0.01. H. TIMP-4 expression in pediatric IDC LV normalized to NF controls. Significance was determined by unpaired Student’s t-test with Welch’s correction: p = 0.006. I. Comparison of TIMP-4 expression in pediatric fibrotic and non-fibrotic IDC hearts. Significance was determined by one way ANOVA with Sidak’s multiple comparison test: NF v fibrosis p = 0.03.