Table 1.
Characteristics of women diagnosed with CRC across tumor composite scores for cytotoxic T lymphocytes (CTL) and granzyme B (GZMB)a.
| CTL composite tumor score n=465 | GZMBcomposite tumor score n=458 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Participant's characteristics (%) | 2-3.9 n=103 22.2 (%) | 4-5.1 n=139 29.9 (%) | 5.2-6.2 n=108 23.2 (%) | ≥6.3 n=115 24.7 (%) | P-valuee | 2 n=196 47.7% | 2.1-2.9 n=92 24.9% | ≥3 n=170 26.5% | P-valuee |
| Age at CRC diagnosis | |||||||||
| ≤ 71 y | 41.8 | 28.1 | 32.4 | 23.5 | 36.7 | 31.5 | 23.5 | ||
| 72-77 y | 32.0 | 46.0 | 39.8 | 38.3 | 40.3 | 39.1 | 38.8 | ||
| >77 y | 26.2 | 25.9 | 27.8 | 38.3 | 0.04 | 23.0 | 29.4 | 37.7 | 0.02 |
|
| |||||||||
| BMIb | |||||||||
| <25 kg/m2 | 35.9 | 36.0 | 38.0 | 34.8 | 41.3 | 29.4 | 35.9 | ||
| 25-30 kg/m2 | 37.9 | 35.3 | 31.5 | 34.8 | 33.7 | 43.5 | 31.2 | ||
| >30 kg/m2 | 26.2 | 28.8 | 30.6 | 30.4 | 0.98 | 25.0 | 27.2 | 32.9 | 0.12 |
|
| |||||||||
| Smokingb | |||||||||
| Current | 8.8 | 20.3 | 10.6 | 12.2 | 14.4 | 13.0 | 13.3 | ||
| Former | 18.6 | 16.7 | 23.1 | 23.5 | 21.7 | 19.6 | 19.3 | ||
| Never | 72.6 | 63.0 | 66.4 | 64.4 | 0.12 | 63.9 | 67.4 | 67.5 | 0.96 |
|
| |||||||||
| Stage at diagnosis | |||||||||
| In situ or local | 30.1 | 23.0 | 42.6 | 37.4 | 24.5 | 35.9 | 40.6 | ||
| Regional | 39.8 | 44.6 | 38.0 | 42.6 | 45.4 | 38.0 | 38.8 | ||
| Distant | 22.3 | 18.0 | 8.3 | 3.5 | 20.4 | 14.1 | 4.1 | ||
| Unknown | 7.8 | 14.4 | 11.1 | 16.5 | 0.0008 | 9.7 | 12.0 | 16.5 | <.0001 |
|
| |||||||||
| Grade | |||||||||
| Well differentiated | 4.9 | 4.3 | 11.1 | 1.7 | 5.1 | 7.6 | 4.1 | ||
| Moderately differentiated | 61.2 | 59.7 | 65.7 | 54.8 | 58.2 | 62.0 | 62.4 | ||
| Poorly differentiated | 26.2 | 33.1 | 18.5 | 40.9 | 31.1 | 23.9 | 31.8 | ||
| Lymphomas/not stated | 7.8 | 2.9 | 4.6 | 2.6 | 0.003 | 5.6 | 6.5 | 1.8 | 0.28 |
|
| |||||||||
| CRC site | |||||||||
| Proximal Colon | 53.9 | 51.1 | 44.9 | 78.3 | 50.3 | 51.1 | 69.2 | ||
| Distal Colon/Rectal | 46.1 | 48.9 | 55.1 | 21.7 | <0.0001 | 49.7 | 48.9 | 30.8 | 0.0005 |
|
| |||||||||
| Surgeryd | |||||||||
| No | 29.1 | 42.5 | 29.6 | 43.5 | 29.6 | 38.0 | 44.7 | ||
| Yes | 70.9 | 57.6 | 70.4 | 56.5 | 0.03 | 70.4 | 62.0 | 55.3 | 0.01 |
|
| |||||||||
| Chemotherapyd | |||||||||
| No | 67.0 | 79.1 | 78.7 | 78.1 | 73.0 | 73.9 | 86.5 | ||
| Yes | 33.0 | 20.9 | 21.3 | 21.9 | 0.008 | 27.0 | 26.1 | 13.5 | 0.004 |
|
| |||||||||
| Radiationd | |||||||||
| No | 95.0 | 97.7 | 96.3 | 99.1 | 94.8 | 98.9 | 98.2 | ||
| Yes | 5.0 | 2.3 | 3.7 | 0.9 | 0.43 | 5.2 | 1.1 | 1.8 | 0.09 |
a
Tumor CTL and GZMB composite scores were created as a sum of corresponding epithelial and stromal scores categorized into quartiles for CTL and tertiles for GZMB.
b
Value at the CRC diagnosis.
c
Value at baseline (in 1986).
d
Initial course of therapy.
e
P-values were based on chi-square test.