Table 3.
Association between cumulative tobacco smoke exposures and the number of deletions in the child’s leukemia using multivariable Poisson regressions, the California Childhood Leukemia Study, 1995–2015.
| Cumulative exposuresa | # Cases | RM | 95% CI | P-valueb |
|---|---|---|---|---|
| Number of exposures (continuous) | 518 | 1.14 | (1.06, 1.22) | 0.0004c |
| Number of exposures (categorical) | ||||
| 0 | 349 | 1 (ref) | ||
| 1 | 83 | 1.14 | (0.90, 1.44) | 0.27 |
| 2 | 34 | 1.18 | (0.84, 1.67) | 0.34 |
| 3 | 22 | 1.60 | (1.10, 2.31) | 0.01c |
| 4 | 30 | 1.64 | (1.18, 2.28) | 0.003c |
a
Cumulative tobacco exposures calculated from the bivariate exposures: paternal smoking during preconception, maternal smoking during preconception, maternal smoking during pregnancy, and child’s postnatal passive smoking.
b
P-values adjusted for age-at-diagnosis, sex, paternal age, and household education;
c
Significant at P<0.05.
RM = ratio of the means.