Table 4.
Association between neonatal DNA methylation at the AHRR CpG cg05575921 and the number of deletions in 198 B-ALL cases by sex using multivariable Poisson regression, the California Childhood Leukemia Study, 1995–2015.
| Biomarker of maternal smoking during pregnancy | B-ALL cases | RM b | 95% CI | P-value a |
|---|---|---|---|---|
| AHRR cg05575921 methylation | Total (n = 198) | 1.32 | (1.02,1.69) | 0.031c |
| Males only (n = 107) | 1.45 | (1.05, 2.00) | 0.023c | |
| Females only (n = 91) | 1.28 | (0.82, 2.00) | 0.277 |
a
Poisson regression model adjusted for cell-mixture, sex, gestational age, ethnicity, DNA methylation array batch number and genotype at SNP rs148405299.
b
RM = ratio of the means, calculated for a 0.1 beta-value decrease in cg05575921 methylation.
c
Significant at P<0.05.