Table 2.
Relation of clinical and imaging variables to molecular tumor markers. For EGFR and MGMT promoter methylation, mean values in positive vs. negative subgroups are listed; the P value refers to the Mann-Whitney U test. For Ki-67 labeling, correlation coefficients (Spearman’s) and related P values are listed. Statistically significant values (P<.05) are in bold.
| Variables | EGFR | MGMT | Ki-67 | |||||
|---|---|---|---|---|---|---|---|---|
| Positive | Negative |
P value |
Positive | Negative |
P value |
r value |
P value |
|
| Age (years) | 64 | 62 | 0.8 | 67 | 59 | 0.1 | 0.21 | 0.4 |
|
Performance status |
83 | 82 | 0.6 | 86 | 80 | 0.9 | 0.07 | 0.8 |
| Survival (days) | 651 | 506 | 0.2 | 746 | 493 | 0.4 | 0.2 | 0.3 |
|
T1-Gad volume (cm3) |
6 | 21.3 | 0.04 | 11.7 | 16.1 | 0.5 | −0.58 | 0.005 |
| T2 volume (cm3) | 36.4 | 44.8 | 0.9 | 48.8 | 40.9 | 0.1 | −0.1 | 0.6 |
| T1/T2 volume | 0.14 | 0.52 | 0.04 | 0.19 | 0.49 | 0.2 | −0.47 | 0.03 |
|
PET volume (cm3) |
52.7 | 41.3 | 0.6 | 23.2 | 48.3 | 0.045 | −0.2 | 0.5 |
| T1/PET volume | 0.14 | 0.56 | 0.02 | 0.51 | 0.34 | 0.9 | −0.5 | 0.02 |
| PET SUV-ratio | 2.4 | 2.1 | 0.2 | 2 | 2.3 | 0.3 | 0.04 | 0.9 |
| PET VD-ratio | 3.6 | 2.4 | 0.1 | 2.8 | 2.8 | 0.7 | 0.1 | 0.7 |
| PET K-ratio | 1.7 | 1.9 | 0.7 | 1.3 | 2 | 0.009 | −0.1 | 0.7 |
Abbreviation: PET= positron emission tomography, EGFR= epidermal growth factor receptor, MGMT=O6-methylguanine-DNA methyltransferase, SUV= standardized uptake value, VD= volume of distribution, T1-Gad= post-contrast T1