Table 2.

Demographic and Clinical Factors in Study Cohort

Variable		Overall Cohort	Study 1 “Specificity”	Study 2 “Cutoff”	Study 3 “Deep-C”	P-value
Patients, n		1050	485	228	337
Median age (IQR), years		65.6 (56.8, 72.3)	64.1 (56.6, 71.8)	62.4 (53.0, 70.9)	68.5 (65.0, 73.8)	<0.0001
Women, n (%)		563 (54)	257 (53)	119 (52)	187 (55)	0.70
White race, n (%)		981 (93)	437 (90)	216 (95)	328 (97)	<0.0001
Patient status by specificity cut-off
Per-protocol (90%)
FP, n (%)		160(15)	65 (13)	36 (16)	59 (18)	0.27
TN, n (%)		890 (85)	420 (87)	192 (84)	278 (82)
Calibrated (90%)
FP, n (%)		113 (11)	53 (11)	25 (11)	35 (10)	1.00
TN, n (%)		937 (89)	432 (89)	203 (89)	302 (90)
Calibrated (95%)
FP n (%)		51 (5)	25 (5)	10 (4)	16 (5)	0.93
TN, n (%)		999 (95)	460 (95)	218 (96)	321 (95)

IQR, Interquartile Range; FP, False Positive; TN, True Negative