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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Mol Cancer Res. 2017 Jan 17;15(4):489–497. doi: 10.1158/1541-7786.MCR-16-0176

Fig. 2. FoxO1 mediates Tam-stimulated IGFBP-1 transcription and inhibition of IGF-1-dependent cell signaling in MCF-7 cells.

Fig. 2

A, FoxO1 expression after siRNA knockdown MCF-7 cells. B, qPCR analysis of 1 µM Tam-induced IGFBP-1 transcription after FoxO1 knockdown in MCF-7 cells. C, Tam-dependent inhibition of IGF-1-stimulated phospho-AKT accumulation is decreased after FoxO1 knockdown in MCF-7 cells. D, CREB expression and accumulation of p-CREB after 1 µM Tam treatment after FoxO1 knockdown in MCF-7 cells. E, Relative qPCR analysis of FoxO1 transcription in 1 μM Tam-treated MCF-7 cells. * = p < 0.05 and results are average or representative of three independent experiments. Error bars are SEM.