Fig. 5. IGF-1R knockdown induces the accumulation decreased FoxO1 protein levels.
A, FoxO1 expression over 48 h after IGF-1R knockdown in MCF-7. B, Accumulation of p-ERK1/2 after IGF-1R knockdown in MCF-7 cells. C, Accumulation of p-ERK1/2 in MCF-7 and TamR cells. * = p < 0.05 and results are average or representative of three independent experiments. Error bars are SEM.