Table 1.
Summary of cohort studies included in the Rare Cancer Collaboration (Gallbladder Cancer)
| Study Name (Acronym) | Gender | Baseline cohort sample size |
Gallbladder cancer case |
Baseline Age |
Baseline BMI (kg/m2) |
Baseline BMI ≥30 kg/m2 |
WC (cm)* | Baseline WC Men: ≥110 cm Women: ≥90 cm* |
Current cigarette smoker* |
Alcohol intake (grams/day) among drinkers* |
Any alcohol intake* |
History of Gallstones* |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | N | Mean (SD) | Mean (SD) | % | Mean (SD) | % | % | Mean (SD) | % | % | ||
| NIH-AARP Diet and Health Study (NIH-AARP) | Women | 191,306 | 57 | 61.3 (5.4) | 26.9 (5.6) | 23.3 | 84.6 (13.4) | 30.7 | 14.5 | 8.5 (20.9) | 70.6 | 13.7 |
| Men | 296,183 | 53 | 61.5 (5.4) | 27.3 (4.2) | 21.4 | 97.9 (11.0) | 13.0 | 11.0 | 22.9 (51.1) | 78.9 | 6.5 | |
|
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| Agricultural Health Study (AHS) | Women | 21,643 | 4 | 46.7 (12.0) | 25.9 (4.9) | 18.6 | -- | -- | 10.1 | 2.9 (6.1) | 55.6 | -- |
| Men | 20,464 | 4 | 47.4 (13.0) | 27.5 (4.1) | 23.4 | -- | -- | 14.3 | 8.3 (14.6) | 67.5 | -- | |
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| The Breast Cancer Detection Demonstration Project (BCDDP) | Women | 37,793 | 8 | 61.2 (8.0) | 25.1 (4.6) | 13.2 | 81.9 (11.8) | 21.2 | 12.8 | 8.0 (14.2) | 48.9 | 12.4 |
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| Cohort of Swedish Men (COSM) | Men | 42,790 | 9 | 60.0 (9.6) | 25.8 (3.4) | 10.1 | 96.0 (10.1) | 9.0 | 24.7 | 15.4 (23.5) | 91.3 | 11.3 |
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| Cancer Prevention Study-II (CPS-II) | Women | 80,354 | 43 | 62.1 (6.6) | 25.6 (4.7) | 15.7 | 86.3 (13.0) | 35.1 | 8.6 | 9.0 (13.1) | 52.4 | 17.1 |
| Men | 71,304 | 21 | 63.9 (6.1) | 26.4 (3.7) | 14.4 | 98.8 (10.1) | 12.7 | 9.1 | 17.1 (21.6) | 65.7 | 9.0 | |
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| California Teachers’ Study (CTS) | Women | 103,811 | 21 | 51.4 (13.5) | 24.8 (5.0) | 13.9 | 81.7 (13.0) | 23.6 | 5.0 | 11.3 (9.7) | 66.7 | 6.4 |
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| European Prospective Investigation into Cancer and Cancer and Nutrition (EPIC) | Women | 254,169 | 61 | 50.4 (10.7) | 25.5 (4.6) | 15.2 | 81.2 (11.5) | 21.4 | 20.2 | 9.6 (12.0) | 83.6 | 9.2 |
| Men | 143,357 | 24 | 51.7 (10.1) | 26.5 (3.7) | 15.5 | 95.1 (10.3) | 8.1 | 29.9 | 21.8 (23.7) | 93.4 | 4.2 | |
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| Iowa Women’s Health Study (IWHS) | Women | 37,506 | 54 | 61.5 (4.2) | 26.1 (4.9) | 18.5 | 69.4 (10.9) | 4.9 | 14.7 | 8.9 (13.1) | 43.6 | -- |
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| Melbourne Collaborative Cohort Study (MCCS) | Women | 22,197 | 17 | 54.3 (8.6) | 26.8 (4.9) | 22.3 | 80.1 (11.8) | 20.0 | 9.0 | 12.4 (14.2) | 57.6 | 12.2 |
| Men | 15,537 | 4 | 54.9 (8.8) | 27.2 (3.6) | 19.1 | 93.5 (10.0) | 6.2 | 14.8 | 24.7 (25.3) | 81.3 | 4.7 | |
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| New York University Women’s’ Health Study (NYUWHS) | Women | 13,211 | 4 | 50.2 (8.7) | 24.9 (4.6) | 12.7 | 75.1 (11.7) | 10.8 | 18.0 | 13.3 (14.4) | 42.0 | 5.0 |
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| Physicians’ Health Study (PHS) | Men | 28,108 | 7 | 54.7 (9.7) | 25.1 (3.0) | 6.2 | -- | -- | 9.2 | -- | -- | 3.7 |
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| Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) | Women | 68,905 | 22 | 62.5 (5.4) | 27.1 (5.5) | 24.9 | -- | -- | 9.5 | 5.6 (14.0) | 99.9 | 16.7 |
| Men | 68,964 | 15 | 62.7 (5.3) | 27.6 (4.2) | 23.4 | -- | -- | 11.5 | 16.5 (33.1) | 99.9 | 7.5 | |
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| The Sister Study (SISTERS) | Women | 47,551 | 3 | 55.0 (9.0) | 27.8 (6.2) | 29.6 | 86.3 (14.7) | 36.0 | 8.3 | 6.8 (10.0) | 95.4 | 14.5 |
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| Swedish Mammography Cohort (SMC) | Women | 33,718 | 32 | 61.3 (9.1) | 25.0 (4.0) | 10.6 | 83.6 (10.7) | 26.4 | 23.6 | 6.9 (10.2) | 83.5 | 19.7 |
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| Shanghai Men’s Health Study (SMHS) | Men | 60,885 | 19 | 54.8 (9.7) | 23.7 (3.1) | 2.6 | 85.1 (8.7) | 0.5 | 58.7 | 35.4 (32.3) | 33.4 | 7.5 |
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| Shanghai Women’s Health Study (SWHS) | Women | 74,460 | 57 | 52.1 (9.1) | 24.0 (3.4) | 5.2 | 77.9 (8.8) | 10.4 | 2.4 | 10.4 (13.9) | 1.9 | 11.3 |
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| Vitamins and Lifestyle Study (VITAL) | Women | 30,842 | 7 | 60.7 (7.4) | 27.2 (5.8) | 25.3 | -- | -- | 7.6 | 9.4 (13.1) | 57.9 | -- |
| Men | 30,866 | 4 | 60.6 (7.3) | 27.6 (4.4) | 23.9 | -- | -- | 8.9 | 17.4 (21.8) | 70.1 | -- | |
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| Women’s Health Study (WHS) | Women | 38,686 | 10 | 54.2 (7.0) | 26.0 (5.1) | 18.2 | -- | -- | 13.1 | 8.6 (11.1) | 56.6 | 9.9 |
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| Women’s Lifestyle and Health Study (WLH) | Women | 44,191 | 7 | 40.2 (5.8) | 23.5 (3.6) | 5.8 | 77.0 (9.3) | 9.6 | 20.9 | 4.1 (4.5) | 86.2 | -- |
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| All Women | Women | 1,100,343 | 407 | 55.4 (10.7) | 25.8 (5.0) | 17.1 | 81.3 (12.5) | 22.3 | 13.2 | 8.6 (14.0) | 66.5 | 12.1 |
| N (%) missing | -- | -- | -- | -- | -- | 36.2 | 36.2 | 1.6 | 5.9 | 5.9 | 20.4 | |
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| All Men | Men | 778,458 | 160 | 58.6 (9.0) | 26.7 (4.0) | 17.3 | 95.1 (11.2) | 9.2 | 19.0 | 21.3 (38.6) | 77.7 | 6.7 |
| N (%) missing | -- | -- | -- | -- | -- | 44.8 | 44.8 | 2.1 | 10.0 | 10.0 | 14.0 | |
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| All Combined | All | 1,878,801 | 567 | 56.7 (10.1) | 26.1 (4.7) | 17.2 | 86.5 (13.8) | 17.4 | 15.6 | 14.2 (28.4) | 71.0 | 9.8 |
| N (%) missing | -- | -- | -- | -- | -- | 39.7 | 39.7 | 1.8 | 7.6 | 7.6 | 17.8 | |
Abbreviations: BMI, body mass index; WC, waist circumference
*
Among non-missing responders