Table 3.
Associations of Waist Circumference, Waist to Height Ratio, Hip Circumference, and Waist to Hip Ratio with Gallbladder Cancer
| All
|
Women
|
Men
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case* | Minimally- Adjusted RR (95% CI)† |
Multivariable- Adjusted RR1 (95% CI)‡ |
Multivariable- Adjusted RR2 (95% CI)§ |
Case* | Minimally- Adjusted RR (95% CI)† |
Multivariable- Adjusted RR1 (95% CI)‡ |
Multivariable- Adjusted RR2 (95% CI)§ |
Case* | Minimally- Adjusted RR (95% CI)† |
Multivariable- Adjusted RR1 (95% CI)‡ |
Multivariable- Adjusted RR2 (95% CI)§ |
|
| Waist Circumference (cm) | ||||||||||||
| M <90, W <70 | 59 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 36 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 23 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| M 90–<100, W 70–<80 | 99 | 1.30 (0.92–1.82) | 1.26 (0.90–1.78) | 1.25 (0.87–1.80) | 73 | 1.42 (0.93–2.18) | 1.37 (0.89–2.10) | 1.38 (0.88–2.16) | 26 | 1.07 (0.59–1.92) | 1.04 (0.58–1.87) | 0.78 (0.40–1.53) |
| M 100–<110, W 80–<90 | 110 | 1.87 (1.31–2.66) | 1.72 (1.21–2.46) | 1.68 (1.11–2.55) | 87 | 1.93 (1.26–2.98) | 1.73 (1.12–2.67) | 1.77 (1.08–2.91) | 23 | 1.80 (0.96–3.37) | 1.69 (0.90–3.19) | 1.17 (0.54–2.55) |
| M 110+, W 90+ | 93 | 2.45 (1.68–3.55) | 2.08 (1.42–3.05) | 2.03 (1.23–3.35) | 79 | 2.46 (1.57–3.85) | 2.02 (1.28–3.19) | 2.09 (1.16–3.77) | 14 | 2.79 (1.36–5.75) | 2.46 (1.17–5.13) | 1.83 (0.68–4.92) |
| Per 5 cm | 1.12 (1.08–1.17) | 1.10 (1.05–1.15) | 1.09 (1.02–1.17) | 1.12 (1.06–1.17) | 1.09 (1.03–1.14) | 1.09 (1.02–1.18) | 1.15 (1.04–1.26) | 1.12 (1.02–1.24) | 1.08 (0.94–1.24) | |||
| p-value for trend | <0.0001 | 0.0001 | 0.0076 | <0.0001 | 0.0015 | 0.0157 | 0.0051 | 0.0191 | 0.2981 | |||
| p-interaction with sex | 0.62 | 0.47 | 0.46 | |||||||||
| Per Std Dev | 1.38 (1.22–1.55) | 1.29 (1.14–1.46) | 1.27 (1.07–1.52) | 1.36 (1.19–1.55) | 1.26 (1.09–1.45) | 1.28 (1.05–1.57) | 1.46 (1.12–1.90) | 1.38 (1.05–1.81) | 1.23 (0.83–1.82) | |||
| Waist to Height Ratio | ||||||||||||
| M <0.50, W <0.45 | 71 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 60 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 11 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| M 0.50–<0.55, W 0.45–<0.50 | 85 | 1.25 (0.90–1.74) | 1.20 (0.86–1.67) | 1.15 (0.81–1.63) | 56 | 1.15 (0.78–1.69) | 1.09 (0.74–1.60) | 1.05 (0.70–1.57) | 29 | 1.66 (0.82–3.36) | 1.63 (0.81–3.30) | 1.50 (0.67–3.36) |
| M 0.55–<0.60, W 0.50–<0.55 | 100 | 1.78 (1.28–2.48) | 1.62 (1.16–2.26) | 1.47 (1.00–2.17) | 72 | 1.65 (1.13–2.41) | 1.45 (0.99–2.13) | 1.38 (0.89–2.13) | 28 | 2.36 (1.16–4.82) | 2.25 (1.10–4.61) | 1.72 (0.70–4.26) |
| M 0.60+, W 0.55+ | 105 | 2.00 (1.43–2.81) | 1.67 (1.18–2.37) | 1.42 (0.90–2.27) | 87 | 1.90 (1.30–2.76) | 1.52 (1.03–2.25) | 1.38 (0.82–2.32) | 18 | 2.44 (1.12–5.31) | 2.22 (1.01–4.90) | 1.51 (0.52–4.37) |
| Per 0.1 | 1.42 (1.23–1.63) | 1.30 (1.12–1.50) | 1.24 (1.00–1.54) | 1.41 (1.21–1.64) | 1.27 (1.08–1.50) | 1.29 (1.02–1.63) | 1.46 (1.04–2.05) | 1.37 (0.97–1.94) | 1.06 (0.63–1.80) | |||
| p-value for trend | <0.0001 | 0.0005 | 0.0497 | <0.0001 | 0.0032 | 0.0371 | 0.0289 | 0.0751 | 0.8187 | |||
| p-interaction with sex | 0.83 | 0.71 | 0.72 | |||||||||
| Per Std Dev | 1.30 (1.17–1.45) | 1.22 (1.09–1.36) | 1.18 (1.00–1.39) | 1.30 (1.15–1.45) | 1.20 (1.06–1.36) | 1.21 (1.01–1.45) | 1.33 (1.03–1.72) | 1.27 (0.98–1.65) | 1.05 (0.70–1.56) | |||
| Hip Circumference (cm) | ||||||||||||
| M <95, W <90 | 55 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 42 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 13 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| M 95–<105, W 90–<100 | 109 | 1.70 (1.14–2.54) | 1.67 (1.12–2.49) | 1.66 (1.09–2.53) | 84 | 2.12 (1.31–3.43) | 2.05 (1.26–3.32) | 2.11 (1.25–3.55) | 25 | 0.98 (0.49–1.96) | 0.98 (0.49–1.96) | 0.78 (0.35–1.70) |
| M 105–<115, W 100–<110 | 93 | 2.15 (1.39–3.32) | 2.00 (1.29–3.09) | 1.92 (1.17–3.17) | 69 | 2.15 (1.28–3.63) | 1.95 (1.15–3.30) | 2.01 (1.09–3.69) | 24 | 2.44 (1.17–5.07) | 2.33 (1.11–4.88) | 1.54 (0.63–3.78) |
| M 115+, W 110+ | 61 | 3.52 (2.20–5.64) | 2.93 (1.82–4.73) | 2.74 (1.48–5.08) | 54 | 3.77 (2.18–6.52) | 3.04 (1.74–5.32) | 3.24 (1.55–6.75) | 7 | 3.50 (1.31–9.35) | 3.01 (1.11–8.17) | 1.96 (0.58–6.68) |
| Per 5 cm | 1.17 (1.11–1.23) | 1.13 (1.07–1.20) | 1.13 (1.04–1.22) | 1.16 (1.09–1.22) | 1.12 (1.05–1.19) | 1.14 (1.05–1.24) | 1.22 (1.07–1.38) | 1.19 (1.04–1.35) | 1.10 (0.92–1.30) | |||
| p-value for trend | <0.0001 | <0.0001 | 0.0021 | <0.0001 | 0.0000 | 0.0028 | 0.0024 | 0.0095 | 0.3044 | |||
| p-interaction with sex | 0.49 | 0.35 | 0.34 | |||||||||
| Per Std Dev | 1.37 (1.23–1.53) | 1.30 (1.16–1.45) | 1.28 (1.09–1.50) | 1.35 (1.20–1.52) | 1.27 (1.12–1.44) | 1.31 (1.10–1.56) | 1.50 (1.15–1.95) | 1.42 (1.09–1.86) | 1.21 (0.84–1.73) | |||
| Waist to Hip Ratio | ||||||||||||
| M <0.90, W <0.75 | 43 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 27 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 16 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| M 0.90–<0.95, W 0.75–<0.80 | 94 | 1.48 (1.03–2.13) | 1.42 (0.99–2.05) | 1.35 (0.94–1.96) | 70 | 1.56 (1.00–2.43) | 1.47 (0.94–2.30) | 1.43 (0.91–2.24) | 24 | 1.35 (0.71–2.58) | 1.31 (0.69–2.50) | 1.13 (0.58–2.21) |
| M 0.95–<1.00, W 0.80–<0.85 | 81 | 1.34 (0.92–1.96) | 1.23 (0.84–1.81) | 1.11 (0.75–1.64) | 66 | 1.40 (0.89–2.21) | 1.26 (0.80–1.99) | 1.17 (0.74–1.87) | 15 | 1.23 (0.60–2.54) | 1.14 (0.55–2.37) | 0.83 (0.38–1.81) |
| M 1.00+, W 0.85+ | 99 | 1.65 (1.13–2.40) | 1.43 (0.98–2.09) | 1.19 (0.80–1.79) | 85 | 1.69 (1.08–2.64) | 1.43 (0.91–2.24) | 1.27 (0.79–2.03) | 14 | 1.69 (0.80–3.60) | 1.49 (0.70–3.20) | 0.96 (0.42–2.20) |
| Per 0.1 | 1.19 (1.03–1.37) | 1.12 (0.96–1.31) | 1.03 (0.87–1.22) | 1.17 (0.99–1.38) | 1.09 (0.92–1.30) | 1.03 (0.85–1.25) | 1.26 (0.97–1.66) | 1.22 (0.89–1.66) | 1.04 (0.70–1.53) | |||
| p-value for trend | 0.0197 | 0.1496 | 0.7076 | 0.0655 | 0.3229 | 0.7456 | 0.0876 | 0.2102 | 0.8482 | |||
| p-interaction with sex | 0.63 | 0.45 | 0.42 | |||||||||
| Per Std Dev | 1.18 (1.03–1.36) | 1.12 (0.96–1.30) | 1.03 (0.88–1.22) | 1.16 (0.99–1.37) | 1.09 (0.92–1.29) | 1.03 (0.86–1.24) | 1.25 (0.97–1.63) | 1.21 (0.90–1.64) | 1.04 (0.71–1.51) | |||
Abbreviations: RR, relative risk; CI, confidence interval
*
Some counts do not add to totals because of missing data
†
Adjusted for age, sex, and study
‡
Adjusted for age, sex, study, race, physical activity, education, smoking, alcohol, and gallstones
§
Adjusted for age, sex, study, race, physical activity, education, smoking, alcohol, gallstones, and BMI