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. Author manuscript; available in PMC: 2018 Apr 15.
Published in final edited form as: J Immunol. 2017 Mar 3;198(8):3345–3364. doi: 10.4049/jimmunol.1601291

FIGURE 8.

FIGURE 8

Upstream Regulator Analysis. Upstream regulator analysis was conducted to determine transcription factors regulating the proteins in cluster 3. Shown are the overlap P-value measuring network enrichment and activation Z-score for each of two networks. (A). ETS homologous factor (EHF) network. Shown is a downregulated network (blue) with an activation Z-score of -2.53. Abbreviations: EHF, ets homologous factor; KLK, Kallikrein-like peptidase; SPRR3, small proline-rich protein 3; MUC, mucin; SAA, serum amyloid A. (B). Upregulated NFκB network. This network is activated by RSV with an activation Z score of +2.131. Abbreviations: BMP, bone morphogenic protein; MMP, matrix metalloproteinase; TIMP, metalloproteinase inhibitor; SOD, superoxide dismutase.