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. Author manuscript; available in PMC: 2018 Apr 3.
Published in final edited form as: Curr Biol. 2017 Mar 23;27(7):1055–1061. doi: 10.1016/j.cub.2017.02.037

Figure 1. Astrocytes targeted in the SCN with the Aldh1L1-Cre/+ mouse line.

Figure 1

Astrocyte nuclei in the SCN were labeled in green by Cre-mediated recombination of Aldh1L1-Cre/+;LSL-GFPNLS/+ mice. Coronal brain sections were immunostained for an astroglial marker, GFAP (A), a neuronal marker, FOX2 (B) or a circadian clock protein, BMAL1(C) in red and all nuclei were counter stained with DAPI. Cells within the yellow boxes (left) were magnified (right). Filled arrowheads indicate double-labeled cells and arrows point to cells that showed no red and green colocalization. Note that Aldh1L1-positive cells reliably express the astrocyte marker, GFAP, and the circadian clock protein, BMAL1, but not the neuronal marker, FOX2. Scale bar = 75 μm. See also Figure S1.