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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Mol Neurobiol. 2016 Oct 5;54(8):6174–6186. doi: 10.1007/s12035-016-0146-2

Figure 7. Effect of the articular blockade of P2X3 and P2X2/3 receptors on carrageenan-induced neutrophil migration.

Figure 7

Induction of joint inflammation with carrageenan (Cg, 300 μg/knee) significantly increased the neutrophil migration into the rat’s knee joint 3 hours after carrageenan injection. The co-administration of the P2X3 and P2X2/3 receptors antagonist A-317491 (540 μg/knee) with carrageenan significantly reduced the carrageenan-induced increase of neutrophil migration, as indicated by the symbol “#” (P<0.05, Tukey test). The symbol “*” indicates a response significantly greater than that of 0.9% NaCl and naive groups (P<0.05, Tukey test).