TABLE 4.

A-RAIL and P-RAIL Algorithms used with Cut off (Logit) Values^‡

Name	Algorithms for predicting Lupus Nephritis activity†	Logit Cut-off
A-RAIL
Creatinine adjusted (1a)	0.21 +0.67*NGAL +0.28*MCP1 −0.12*Ceruloplasmin +0.88*Adiponectin −0.25*Hemopexin −0.05*KIM1	−0.97
Absolute amounts (1b)	−5.05 +0.56*NGAL +0.12*MCP1 −0.29*Ceruloplasmin +0.88*Adiponectin +0.01*Hemopexin +0.02*KIM1	−1.92
Albumin adjusted (1c)	3.47 +0.43*NGAL +0.16*MCP1 −0.23*Ceruloplasmin +0.81*Adiponectin −0.05*Hemopexin −0.62*KIM1	−2.06
P-RAIL
Creatinine adjusted (2)	−4.29 −0.34*NGAL +0.89* MCP1 −0.06*ceruloplasmin +0.18* Adiponectin −0.65*Hemopexin +0.62*KIM1	−1.87

^‡Parameter estimates used for the algorithms calculated using a logistic regression model with LN activity (NIH-AI) being the dichotomized outcome variable. Please refer to Supplementary Table 1 for details on the parameters ± SE values for individual biomarkers used.

^†Urine biomarkers include: neutrophil gelatinase associated lipocalin (NGAL) [ng/ml], monocyte chemotactic protein 1 (MCP-1) [pg/ml], ceruloplasmin [μg/ml], adiponectin [ng/ml], hemopexin [mg/ml] and kidney injury molecule 1 (KIM-1) [pg/ml].

For (1a), (1b), (1c) and (2): Please refer to Table 3 for details.