In the NAc, meth self-administration altered presynaptic NAc physiology.
In the NAc, long access meth decreased PPR on whole cell recordings (A).
Representative traces for significant findings are depicted below. Also, meth
increased the frequency (B) of sEPSCs but not the amplitude (C). Representative
traces of spontaneous events from three cells of each group are depicted.
The number of cells/animal is indicated in the bar graphs, which
represent the mean; the errors bars represent the SEM.
*Significant difference from saline.