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. 2017 Apr 5;11:175. doi: 10.3389/fnins.2017.00175

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Copyright © 2017 Quinn, Pellissier and Wijnholds.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depiction of CRB-mediated gene therapy strategies. Targeted delivery of CRB exclusively to either the Müller glial cells (MGC) or photoreceptors (PRC) provides no therapeutic benefit (left and middle panels, respectively); in contrast, delivering CRB to both MGCs and PRCs (right panel) elicits a response. Intravitreal applied ShH10Y-CMV-CRB drives CRB expression in the subapical region (SAR) of MGCs, whereas subretinal applied AAV9-GRK1-CRB drives expression at the SAR of photoreceptors. In contrast, subretinal applied AAV9-CMV-CRB drives expression at the SAR of both cell types.