Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 5;8:294. doi: 10.3389/fimmu.2017.00294

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Mourik, Lubberts, de Steenwinkel, Ottenhoff and Leenen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The IL-17/type I interferons (T1-IFNs)/B-cell activating factor (BAFF) axis in tuberculosis (TB). Mtb actively induces NET formation by PMN, but subsequent activation of IFN-α production by plasmacytoid dendritic (pDC) appears less relevant in TB than in autoimmune diseases (AID). IL-17 levels from TB patients vary (Table 3), but preclinical models support a protective role. Dotted lines implicate mechanisms present in AID that have not been confirmed in TB. Outstanding questions: (1) What are the specific contributions of IFN-α vs. IFN-β to disease in the different phases of TB? (2) Do BAFF and T1-IFNs promote the observed autoimmune phenomena in TB?