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Relevant process control parameters, which are used similarly for manufacturing scale as well as for scale-down models
| Control parameters for each process | ||
|---|---|---|
| S/D treatment (scale-down factor: 2696) | IEC (scale-down factor: 9802) | Nanofiltration (scale-down factor: 6875) |
| pH | pH | pH |
| Temperature | Contact time | Pressure |
| Incubation time | Applied amount of target protein | Filter area |
| Concentration of S/D reagents | Temperature | |
IEC ion-exchange chromatography, S/D solvent/detergent
