Table 8.

Heats of formation for intermediates and transition states, where the side-chain of Met192 was replaced with -CH₂CH₃ (kcal mol⁻¹)

Step	ΔHf †	Change‡	Transition state	ΔHf †	Change‡	Barrier Height	Change‡
1	0.00		1 → 2	+18.42	+0.49	18.42	+0.49
2	+2.48	+5.02	2 → 3	+20.35	+2.77	17.87	−2.25
3	−1.19	+3.64	1 → 3	+39.40	+3.54	39.40	+3.54
4	+5.59	+1.30	4 → 5	+14.39	+0.41	8.79	−0.89
5	+1.59	−3.01	5 → 6	+24.35	+3.99	22.76	+7.00
6	−2.51	+3.19

† ΔH_f relative to that of step 1.

‡Changes are relative to the un-mutated system