Table 4.
DAVID analysis to determine GO term enrichment (GOTERM_CC_FAT) for genes coding for proteins of the CF proteome (n = 413) (P < 0,01; FDR 1%)
| GO Term | Count | % | PValue | Bonferroni | FDR |
|---|---|---|---|---|---|
| GO:0005615 ~ extracellular space | 150 | 38.66 | 4.03 E-94 | 1.04E-91 | 5.26E-91 |
| GO:0044421 ~ extracellular region part | 167 | 43.04 | 1.11E-89 | 2.85E-87 | 1.45E-86 |
| GO:0005576 ~ extracellular region | 226 | 58.25 | 4.14E-89 | 1.06E-86 | 5.40E-86 |
| GO:0031226 ~ intrinsic to plasma membrane | 92 | 23.71 | 5.60E-18 | 1.44E-15 | 7.31E-15 |
| GO:0005887 ~ integral to plasma membrane | 90 | 23.20 | 1.41E-17 | 3.63E-15 | 1.84E-14 |
| GO:0009986 ~ cell surface | 43 | 11.08 | 3.29E-15 | 8.56E-13 | 4.34E-12 |
| GO:0044459 ~ plasma membrane part | 116 | 29.90 | 3.79E-11 | 9.75E-09 | 4.95E-08 |
| GO:0009897 ~ external side of plasma membrane | 24 | 6.19 | 7.76E-10 | 2.00E-07 | 1.01E-06 |
| GO:0043235 ~ receptor complex | 19 | 4.90 | 6.19E-09 | 1.59E-06 | 8.08E-06 |
| GO:0031012 ~ extracellular matrix | 31 | 7.99 | 8.64E-08 | 2.22E-05 | 1.13E-04 |
| GO:0060205 ~ cytoplasmic membrane-bounded vesicle lumen | 11 | 2.84 | 3.96E-07 | 1.02E-04 | 5.17E-04 |
| GO:0031983 ~ vesicle lumen | 11 | 2.84 | 6.18E-07 | 1.59E-04 | 8.07E-04 |
| GO:0031093 ~ platelet alpha granule lumen | 10 | 2.58 | 2.09E-06 | 5.37E-04 | 0.002 |
| GO:0005578 ~ proteinaceous extracellular matrix | 27 | 6.96 | 2.32E-06 | 5.97E-04 | 0.003 |
| GO:0005886 ~ plasma membrane | 152 | 39.18 | 2.62E-06 | 6.74E-04 | 0.003 |
| GO:0031091 ~ platelet alpha granule | 11 | 2.84 | 4.17E-06 | 0.001 | 0.005 |
| GO:0030141 ~ secretory granule | 19 | 4.90 | 5.13E-06 | 0.001 | 0.006 |