Table 3.
Significant activation peaks for the 2-back vs. 0-back contrast for each experimental group.
| Subject group | Cluster level | Cluster extent | MNI co-ordinates | t | BA | Peak in cluster | ||
|---|---|---|---|---|---|---|---|---|
| p (FDR) | x | y | Z | |||||
| CONTROLS | ||||||||
| 0.000 | 1181 | 9 | 23 | 46 | 8.58 | 32 | R Superior Medial Frontal | |
| 0 | 20 | 46 | 8.56 | 32 | L Supplementary Motor Area | |||
| −24 | 5 | 58 | 8.49 | 6 | L mid Frontal | |||
| −39 | 8 | 28 | 4.74 | 44 | L Inferior Frontal Operculum | |||
| −48 | 32 | 37 | 4.54 | 45 | L mid frontal | |||
| 0.000 | 726 | 48 | 41 | 19 | 7.94 | 45 | R mid Frontal | |
| 42 | 11 | 52 | 4.35 | 9 | R mid Frontal | |||
| 27 | 23 | 61 | 3.86 | 8 | R Superior Frontal | |||
| 48 | 20 | 34 | 3.74 | 44 | R Inferior Frontal Operculum | |||
| 0.000 | 593 | −33 | −49 | 46 | 8.91 | 40 | L Inferior Parietal | |
| −33 | −58 | 52 | 7.93 | 7 | L Inferior Parietal | |||
| 45 | −40 | 46 | 7.89 | 40 | R Supramarginal Gyrus | |||
| 42 | −46 | 52 | 7.67 | 40 | R Inferior Parietal | |||
| 30 | −64 | 52 | 6.30 | 7 | R Superior Parietal | |||
| 0.000 | 282 | −6 | −64 | 58 | 5.35 | 7 | L Precuneus | |
| 9 | −67 | 49 | 5.30 | 7 | R Precuneus | |||
| 0.000 | 222 | 30 | −73 | −50 | 8.99 | n/a | R Cerebellum 7b | |
| 36 | −61 | −32 | 7.48 | n/a | R Cerebellum Crus 1 | |||
| 0.000 | 117 | −30 | −70 | −50 | 8.75 | n/a | L Cerebellum 7b | |
| −33 | −61 | −32 | 5.80 | n/a | L Cerebellum Crus 1 | |||
| 0.005 | 75 | 36 | 23 | 10 | 6.11 | 48 | R inferior frontal Triangularis | |
| 39 | 23 | −2 | 5.43 | 47 | R Insula | |||
| PLACEBO | ||||||||
| 0.000 | 343 | 42 | −46 | 52 | 7.44 | 40 | R Inferior Parietal | |
| 39 | −73 | 37 | 5.33 | 19 | R mid Occipital | |||
| 33 | −64 | 49 | 5.05 | 7 | R Angular Gyrus | |||
| 0.000 | 270 | −27 | 5 | 55 | 8.82 | 8 | L mid Frontal | |
| −24 | −4 | 55 | 7.33 | 6 | L Superior Frontal | |||
| −6 | 11 | 52 | 7.08 | 6 | L Supplementary Motor Area | |||
| 6 | 20 | 52 | 5.20 | 6 | R Supplementary Motor Area | |||
| 3 | 20 | 43 | 4.55 | 32 | R mid Cingulum | |||
| 0.000 | 168 | −48 | −1 | 40 | 11.96 | 6 | L Precentral | |
| −39 | 23 | 31 | 5.98 | 44 | L Inferior Frontal Triangularis | |||
| −39 | 32 | 34 | 5.69 | 45 | L mid Frontal | |||
| 0.000 | 160 | 27 | 8 | 64 | 6.65 | 6 | R Superior Frontal | |
| 30 | 11 | 52 | 4.95 | 8 | R mid Frontal | |||
| 0.000 | 109 | −36 | −70 | −32 | 6.74 | n/a | L Cerebellum Crus 1 | |
| −24 | −67 | −41 | 4.36 | n/a | L Cerebellum 7b | |||
| 0.001 | 89 | 33 | −70 | −32 | 7.91 | n/a | R Cerebellum Crus 1 | |
| 0.005 | 66 | −30 | −73 | 37 | 6.22 | 7 | L mid occipital | |
| 0.011 | 54 | 51 | 5 | 40 | 5.91 | 6 | R Precentral | |
| 36 | 2 | 28 | 4.85 | 48 | R Inferior Frontal Operculum | |||
| 0.013 | 49 | 9 | −67 | 55 | 6.62 | 18 | R Precuneus | |
| DRUG | ||||||||
| 0.001 | 105 | −48 | −46 | 40 | 5.45 | 40 | L Inferior Parietal | |
| −30 | −64 | 37 | 3.43 | 19 | L mid Occipital | |||
| 0.005 | 72 | 42 | −46 | 43 | 5.02 | 40 | R Inferior Parietal | |
| 48 | −37 | 49 | 4.75 | 7 | R Inferior Parietal | |||
| 0.023 | 47 | 24 | 8 | 58 | 4.89 | 6 | R Superior Frontal | |
| 39 | 8 | 61 | 4.84 | 6 | R mid Frontal | |||