Table 3.

Impact scores for metabolic pathways in CFS.

Time	Pathway Name	Total	Hits	p	−log⁡(p)	Holm p	FDR	Impact score	Ranking list∗
Before exercise	TCA cycle	20	1	0.134	2.008	1.00	1.00	0.068	1
	Alanine, aspartate and glutamate metabolism	24	1	0.159	1.839	1.00	1.00	0.063	2
	Steroid hormone biosynthesis	70	1	0.402	0.912	1.00	1.00	0.015	3
	Purine metabolism	68	1	0.393	0.935	1.00	1.00	0.003	—
	D-Glutamine and D-glutamate metabolism	5	1	0.035	3.347	1.00	1.00	0.000	—
	beta-Alanine metabolism	19	1	0.128	2.056	1.00	1.00	0.000	—
	Propanoate metabolism	20	1	0.134	2.008	1.00	1.00	0.000	—
	Butanoate metabolism	20	1	0.134	2.008	1.00	1.00	0.000	—
	Tryptophan metabolism	41	1	0.258	1.357	1.00	1.00	0.000	—
After exercise	TCA cycle	20	3	0.000	8.181	0.02	0.02	0.140	1
	Alanine, aspartate, and glutamate metabolism	24	2	0.012	4.454	0.93	0.47	0.067	2
	Sphingolipid metabolism	21	1	0.141	1.963	1.00	1.00	0.053	3
	Steroid hormone biosynthesis	70	1	0.402	0.912	1.00	1.00	0.015	4
	D-Glutamine and D-glutamate metabolism	5	1	0.035	3.347	1.00	0.95	0.000	—
	Glyoxylate and dicarboxylate metabolism	16	1	0.109	2.219	1.00	1.00	0.000	—
	Butanoate metabolism	20	1	0.134	2.008	1.00	1.00	0.000	—
	Pyruvate metabolism	22	1	0.147	1.919	1.00	1.00	0.000	—
	Fatty acid elongation in mitochondria	27	1	0.177	1.730	1.00	1.00	0.000	—
	Fatty acid metabolism	39	1	0.247	1.400	1.00	1.00	0.000	—
	Tyrosine metabolism	42	1	0.263	1.336	1.00	1.00	0.000	—
	Biosynthesis of unsaturated fatty acids	42	1	0.263	1.336	1.00	1.00	0.000	—
	Fatty acid biosynthesis	43	1	0.268	1.315	1.00	1.00	0.000	—
	Arginine and proline metabolism	44	1	0.274	1.295	1.00	1.00	0.000	—

^∗Threshold of the impact score >0.01.