Table 2. Top 10 protein–drug pairs with highest number of somatic mutations and germline mutations within two and five amino acids upstream and downstream of binding sites.

Somatic mutations				Germline mutations
UniProtKB Ac	Drug name	2-Score	5-Score	UniProtKB Ac	Drug name	2-Score	5-Score
P00533	Lapatinib	122	191	P69905	L-Methionine	35	62
P00533	Erlotinib	104	171	P19652	Disopyramide	14	16
P00533	Gefitinib	97	153	P10635	Thioridazine	14	18
P15056	Sorafenib	67	108	P00519	Nilotinib	11	15
P00533	Afatinib	37	62	P00519	Imatinib	11	15
P00519	Nilotinib	33	49	P08263	Ethacrynic acid	11	13
P00519	Imatinib	32	49	P00519	Dasatinib	10	22
P00519	Dasatinib	28	44	P02768	Levothyroxine	10	24
P02768	Levothyroxine	24	44	P60022	Glycine	10	20
P00519	Bosutinib	23	44	P00533	Lapatinib	9	13