Figure 6. Acute treatment of stevioside lowers the glycaemia of WT mice during a GTT in a β-cell-dependent way.

(a–f) Results of crossover tandem GTTs performed on the same mice with a 2 week interval. Mice received either 0.5 mg g⁻¹ stevioside applied per os 2 h before the GTT, or vehicle. Individual points represent the average±s.e.m. and the significances are the result of a paired sample t-test of the values at the same time point; non-significant differences are not indicated. (a) WT mice on a normal diet, (b) Trpm5^−/− mice on a normal diet, (c) WT mice 20 weeks on a HFD, (d) Trpm5^−/− mice 20 weeks on a HFD, (e) WT mice with WT islets transplanted under the kidney capsule and (f) WT mice with Trpm5^−/− islets transplanted under the kidney capsule. (g) Average±s.e.m. Area under the curve (AUC) from the experiments in a–f. Paired sample t-test within groups, two-sample t-test between groups. See also Supplementary Figs 10 and 11. NS, not significant.