Table 1.
Characteristics of previously reported cases of listeriosis associated with alemtuzumab reported until February March 3, 2017
| Source (reference) | Type of listeriosis | Gender | Indication | Number of infusions | Days from first infusion to onset | Outcome |
|---|---|---|---|---|---|---|
| VigiBase 2017 (3) | Meningitis | Female | Multiple sclerosis | 5 | Unknown | Unknown |
| VigiBase 2016 (3) | Meningitis | Female | Multiple sclerosis | 5 | 8 | Recovering |
| VigiBase 2016 (3)a | Listeriosis | Male | Not reported | Unknown | Unknown | Died |
| VigiBase 2016 (3) | Meningitis | Female | Multiple sclerosis | 3 | 5 | Recovered |
| VigiBase 2016 (3) | Unknown | Female | Multiple sclerosis | 5 | 17 | Unknown |
| VigiBase 2016 (3) | Unknown | Female | Multiple sclerosis | 5 | 23 | Unknown |
| Sanofi Genzyme, data on file VigiBase 2016 (3) |
Meningoencephalitis | Female | Multiple sclerosis | 5 | 7 | Died |
| VigiBase 2016 (3) | Meningitis | Female | Multiple sclerosis | 5 | 17 | Recovered |
| VigiBase 2016 (3) | Unknown | Female | Multiple sclerosis | 3 | 8 | Recovered |
| VigiBase 2016 (3) | Unknown | Unknown | Multiple sclerosis | 5 | 9 | Unknown |
| VigiBase 2016 (3) | Septicaemia | Female | Multiple sclerosis | Unknown | Unknown | Unknown |
| VigiBase 2015 (3) | Unknown | Male | Multiple sclerosis | 5 | 9 | Recovered |
| VigiBase 20 14 (3) | Meningitis | Female | Multiple sclerosis | 5 | 1 | Not recovered |
| Rau 2015 (4) | Meningitis | Female | Multiple sclerosis | 5 | 6 | Recovered |
| Rau 2015 (4) | Meningitis | Female | Multiple sclerosis | 5 | 8 | Recovered |
| Wray 2009 (5) | Meningitis | Female | Multiple sclerosis | 3 | 19 | Recovered |
| Ohm 2009 (6) | Sepsis | Female | Multiple sclerosis | 3 | 13 | Not recovered |
| VigiBase 2010 | Meningitis | Male | Unknown | NA | Unknown | Not recovered |
| VigiBase 2009 (3) | Unknown | Female | B cell lymphoma | NA | Unknown | Died |
| VigiBase 2010 (3) | Sepsis | Male | Chronic lymphocytic leukemia | NA | Unknown | Unknown |
| VigiBase 2011 | Unknown | Unknown | Chronic lymphocytic leukemia | NA | Unknown | Unknown |
aNo information about the indication for treatment, type of listeriosis or number of infusions is provided at VigiBase for this case
Information in VigiBase comes from a variety of sources, and the likelihood that the suspected adverse reaction is drug-related is not the same in all cases. The information does not represent the opinion of the World Health Organization (3)