Table 3.
Proportional odds ratios (OR) and 95% confidence intervals (CI) for breast cancer severity from a multivariate model, including women from the AMORIS database and the Swedish Breast Cancer Registry between the years 1989–2011. Models were adjusted for age, parity, socioeconomic status, fasting status, total cholesterol, glucose, triglycerides, and interval time (except where stated otherwise)
| All BC w/severity (N = 1411) | Crude Model | Adjusted Model | |
|---|---|---|---|
| N(%) | OR (95%CI) | OR(95%CI) | |
| Total Cholesterol (mmol/l)a | |||
| Log TC | 1.14 (0.66–1.97) | 0.96 (0.51–1.83) | |
| < 6.50 | 1040 (73.71) | 1.00 (ref) | 1.00 (ref) |
| ≥ 6.50 | 371 (26.29) | 1.19 (0.95–1.49) | 1.08 (0.85–1.38) |
| Triglycerides (mmol/l)b | |||
| Log TG | 1.22 (1.00–1.50) | 1.21 (0.96–1.53) | |
| < 1.71 | 1237 (87.67) | 1.00 (ref) | 1.00 (ref) |
| ≥ 1.71 | 174 (12.33) | 1.13 (0.84–1.52) | 1.00 (0.72–1.37) |
| HDL (mmol/l) | |||
| Log HDL | 0.66 (0.45–0.98) | 0.73 (0.44–1.21) | |
| ≥ 1.03 | 1364 (96.67) | 1.00 (ref) | 1.00 (ref) |
| < 1.03 | 47 (3.33) | 1.10 (0.63–1.90) | 0.89 (0.47–1.67) |
| LDL (mmol/l) | |||
| Log LDL | 1.23 (0.87–1.74) | 2.09 (0.92–4.78) | |
| < 4.10 | 1032 (73.14) | 1.00 (ref) | 1.00 (ref) |
| ≥ 4.10 | 379 (26.86) | 1.12 (0.89–1.40) | 1.07 (0.76–1.50) |
| ApoA (g/L) | |||
| Log ApoA | 0.49 (0.25–0.98) | 0.56 (0.27–1.15) | |
| ≥ 1.05 | 1402 (99.36) | 1.00 (ref) | 1.00 (ref) |
| < 1.05 | 9 (0.64) | 2.12 (0.67–6.69) | 1.99 (0.62–6.35) |
| ApoB (g/L) | |||
| Log ApoB | 1.23 (0.82–1.85) | 1.30 (0.60–2.81) | |
| < 1.50 | 1208 (85.61) | 1.00 (ref) | 1.00 (ref) |
| ≥ 1.50 | 203 (14.39) | 1.25 (0.95–1.65) | 1.22 (0.85–1.74) |
| Glucose (mmol/)c | |||
| Log Glucose | 1.76 (0.99–3.14) | 1.63 (0.88–3.01) | |
| < 5.60 | 1231 (87.24) | 1.00 (ref) | 1.00 (ref) |
| ≥ 5.60 | 180 (12.76) | 1.38 (1.04–1.84) | 1.25 (0.92–1.70) |
| Log(TG/HDL)b,c | |||
| Log TG/HDL | 1.19 (1.02–1.39) | 1.16 (0.99–1.38) | |
| < 0.50 | 1317 (93.34) | 1.00 (ref) | 1.00 (ref) |
| ≥ 0.50 | 94 (6.66) | 1.32 (0.90–1.94) | 1.16 (0.78–1.74) |
| LDL/HDL | |||
| Log LDL/HDL | 1.27 (1.00–1.62) | 1.29 (0.93–1.78) | |
| < 3.50 | 1280 (90.72) | 1.00 (ref) | 1.00 (ref) |
| ≥ 3.50 | 131 (9.28) | 1.22 (0.87–1.71) | 1.10 (0.74–1.63) |
| ApoB/ApoA-1 | |||
| Log ApoB/ApoA-1 | 1.38 (0.98–1.95) | 1.37 (0.88–2.15) | |
| < 1.00 | 1165 (82.57) | 1.00 (ref) | 1.00 (ref) |
| ≥ 1.00 | 246 (17.43) | 1.36 (1.05–1.75) | 1.31 (0.97–1.76) |
a Not adjusted for TC; b Not adjusted for TG; c Not adjusted for glucose