Table 3.
G6PD haplotypes and associated phenotypes identified in western Madagascar study sites
| Study site | G6PD FST phenotype | Phenotype frequency | B a | A b | A- c | Mediterranean d |
|---|---|---|---|---|---|---|
| Ampasimpotsy | Normal | 89 | 88 | 1 | 0 | 0 |
| Intermediate | 7 | 4 | 2 | 1 | 0 | |
| Deficient | 11 | 1 | 0 | 10 | 0 | |
| Mandoto/Miandrivazo | Normal | 165 | 159 | 6 | 0 | 0 |
| Intermediate | 9 | 6 | 0 | 3 | 0 | |
| Deficient | 10 | 0 | 0 | 9 | 1 |
Includes samples that were tested by both diagnostic approaches (n = 291)
a B wild-type cDNA sequence, GenBank X03674. 84 B haplotypes carry SNP 1311C > T; 437Y > Y
b A 126N > D associated with nonsynonymous SNP 376A > G. One A haplotype carries SNP 1311C > T; 437Y > Y
c A- 68V > M and 376 N > D associated with nonsynonymous snps 202G > A and 376A > G, respectively. Five A- haplotypes, all from Ampasimpotsy, are 68V > M associated with nonsynonymous snp 202G > A
d Mediterranean 188S > F and 437Y > Y associated with nucleotide snps 563C > T and 1311C > T, respectively