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The impact of linker region on RDP-Linker-GCase binding and internalization in GCKO mouse neurons. The concentrations of GCase detected in the cell lysates for each treatment condition were quantitated and subsequently normalized to Tat-GCase to facilitate comparison. RDP-IgAh-GCase was internalized 2.65× more than Tat-GCase. All bars in the above graph represent the average of duplicate treatment conditions. Error bars indicate one standard deviation.
