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. Author manuscript; available in PMC: 2017 Apr 5.
Published in final edited form as: J Biotechnol. 2016 Jan 18;221:1–12. doi: 10.1016/j.jbiotec.2016.01.015

Table 2.

Comparison of GCase detected in GCKO mouse neuronal cell lysate following protein treatment with 12 μg/mL recombinant GCase. RDP was not found to improve GCase binding and internalization. Neither Tat nor RDP facilitated significantly better protein transduction efficiency compared to commercially available Cerezyme (Genzyme Corp). Detected GCase concentrations represent the average of duplicate treatment conditions with error indicating one standard deviation. The GCase concentrations for the independent repeats can be found in Supplemental Table 1.

Comparison of delivered GCase activity in GCKO mouse neuronal cell lysate
Protein GCase detected (ng/mL) Normalized to Tat-GCase
Tat-GCase 133.17 ± 18.36 1.00
RDP-GCase 117.10 ± 3.96 0.88
Cerezyme 100.82 ± 5.37 0.76