Table 5.
Cox proportional hazards analyses of the prognostic value of risk score in the 664 patients with nasopharyngeal cancer undergoing IMRT
| Endpoint | Variable | HR | HR (95%CI) | P-value a |
|---|---|---|---|---|
| OS | Age (>45 vs. ≤45 years) | 2.87 | 1.56-5.27 | 0.001 |
| Risk score b (high vs. low) | 3.50 | 1.99-6.13 | <0.001 | |
| PFS | Age (>45 vs. ≤45 years) | 1.58 | 1.08-2.32 | 0.018 |
| N category (N1-3 vs. N0) | 1.93 | 1.06-3.72 | 0.048 | |
| Risk score b (high vs. low) | 1.73 | 1.16-2.59 | 0.008 | |
| LRFS | Risk score b (high vs. low) | NS | --- | --- |
| DMFS | Risk score b (high vs. low) | 2.41 | 1.44-4.02 | 0.001 |
Abbreviations: CI = confidence interval; DMFS = distant metastasis-free survival; HR = hazard ratio; IMRT = intensity-modulated radiotherapy; LRFS = locoregional relapse-free survival; NS = not significant; OS = overall survival.
a The following parameters were included in the Cox proportional hazards model multivariate analysis with backward elimination: age (> 45 vs. ≤ 45 years), gender (female vs. male), T category (T3-4 vs. T1-2), N category (N1-3 vs. N0) and chemotherapy (yes vs. no).
b High-risk score, >22.74; low-risk score, ≤22.74