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. 2017 Mar 22;2017:8940321. doi: 10.1155/2017/8940321

Figure 2.

Figure 2

Structure of CBS p.P49L. X-ray crystallographic structure of CBSΔ409–551 p.P49L solved at 2.80 Å resolution (PDB entry 5MMS). (a) Cartoon representation of the protein dimer, each monomer being represented in a different color. Pyridoxal 5′-phosphate (PLP) and heme moieties shown in stick representation. (b) Structure superposition of CBSΔ409–551 p.P49L (PDB entry 5MMS) and truncated WT CBS (PDB entry 1JBQ), both colored in grey except for most relevant regions and residues, where CBSΔ409–551 p.P49L is colored in red and CBSΔ409–551 WT in blue; zoom in on the PLP and heme moieties, highlighting the proline-to-leucine substitution, as well as the R266 residue and α-helix 8 proposed to mediate communication between the heme and the PLP active site. Figure generated with PyMOL 1.8.2 (The PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC).