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. 2014 Apr 28;4:4818. doi: 10.1038/srep04818

Table 2. Summary of therapeutic efficacy for docetaxel combined thlidomide vs. docetaxel alone in AIPC.

Study Regimen Age(years) Median OS (months) Median PFS (months) ≥50%PSA decline (Number) Hematologic toxicities Non-hematologic toxicities
Grade1–2 Grade 3–5 Grade1–2 Grade 3–5            
Sissung TM 2008 docetaxel plus thalidomide N/A N/A N/A N/A N/A 4(5%) N/A 1(1%)
docetaxel N/A N/A N/A            
Dahut WL 2004 docetaxel plus thalidomide 71(52–83) 28.9 5.9 25/47 4(8%) 7(14%) 22(88%) 9(18%)
docetaxel 67(43–82) 14.7 3.7 9/24 4(16%) 7(28%) 41(84%) 2(8%)  
Figg WD 2001 docetaxel plus thalidomide 69(49–80) N/A N/A 19/36 N/A 5(7%) N/A 1(1%)
docetaxel N/A N/A 6/17            

Abbreviation: OS: Overall survival; PFS: Progression-free survival; N/A: not applicable.