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. 2017 Apr 5;7:45473. doi: 10.1038/srep45473

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(A,B) Following a single intraperitoneal injection (i.p.) of 50 μg of rsACE2, tail blood was collected at different time points. ACE2 activity from 0.5 μL serum was measured by either Mca-APK(Dnp) (A) or Ang II phenylalanine assay (B) with or without MLN-4760 inhibition of ACE2. (C) Mca-APK(Dnp) measured endogenous ACE2 activity with or without MLN-4760 in untreated mice serum samples. (D,E) Phenylalanine assay with 5 μL serum from untreated mice using Ang II (D) or apelin-13 (E) as substrate. 5 ng rsACE2 was used as positive control in C through E. The results are expressed as the means ± SD of three independent experiments. (***p < 0.001, n.s: not significant, t test).