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. 2017 Feb 8;7(4):884–898. doi: 10.7150/thno.18219

Figure 6.

Figure 6

Agonistic micelles improve axonal remodeling and reduce behavioral deficits. (A) In vivo DTI demonstrated fiber tract integrity and orientation in the ipsilesional and contralateral inner capsule at 14 days post injection of PBS, free EDV, EDV-AM, or EDV-PM with the same EDV dose (0.078 mg/mouse). White and yellow arrows point to fiber tract in ipsilateral and contralateral IC, respectively. (B) Fractional anisotropy (FA) values determined in the ipsilesional IC at 14 days post treatment (n = 4-5, ** P < 0.01 vs. free EDV group). (C) Kaplan-Meier survival curves of the ischemic stroke models at 1, 4, and 7 days post treatments indicated in Figure 5A. Behavioral deficits in the animal models were evaluated using modified neurological severity scores (D) and foot-fault test (E) before and at 1, 4, 7, and 14 days (n = 5-6 per group). # P < 0.05, ## P < 0.01 vs. PBS group, * P < 0.05 vs. free EDV group. CH: contralateral hemisphere, IH: ipsilateral hemisphere, IC: inner capsule.