Table 1. Parameters of serum chemistry in mice treated with different combinations of siRNA targeting Hippo pathway.
| PBS | si-Control | Triple siRNA | si-Mst2+si-NF2 | si-Mst1+si-NF2 | |
|---|---|---|---|---|---|
| Albumin, g/dl | 2.90±0.12 | 2.89±0.22 | 3.31±0.15* | 3.14±0.17# | 2.96±0.11 |
| Total protein, g/dl | 4.7±0.1 | 4.9±0.2 | 5.5±0.2** | 5.2±0.2## | 5.0±0.2 |
| Globulin, g/dl | 1.82±0.08 | 2.06±0.05 | 2.24±0.11* | 2.1±0.07# | 2.06±0.11 |
| Blood urine nitroqen, mg/dl | 19.2±2.3 | 20.5±2.5 | 18.5±1.9 | 21.4±2.8 | 19.4±1.1 |
| Alkaline phosphatase (ALP), IU/I | 101.5±14.4 | 116.3±17.9 | 209.2±87.4* | 125.8±31.5# | 108.7±10.9# |
| ALT (SGPT), IU/I | 19±2.4 | 24.1 ±8.9 | 50.9±15.7 | 52.9±28.7# | 19.8±1.6 |
| AST (SGOT), IU/I | 47.8±16.8 | 67.4±29.1 | 65.9±3.2 | 83.5±12.1 | 59.7±11.4 |
| Direct bilirubin, mg/dl | 0.04±0.024 | 0.023±0.015 | 0.228±0.189* | 0.042±0.017# | 0.023±0.011# |
| Total bilirubin, mg/dl | 0.178±0.046 | 0.140±0.036 | 0.448±0.244* | 0.186±0.032## | 0.132±0.013# |
| Total bile acids, mg/dl | 6.1±1 | 8.9±2.6 | 91.4±33*** | 25.5±5.6### | 15.1±1.8### |
| Cholesterol, mg/dl | 68.5±10.4 | 76.3±10.2 | 125.6±20.4*** | 87.2±6.6### | 88.7±5### |
| Triglycerides, mg/dl | 90.9±24.3 | 80.5±18.2 | 90.2±10.4 | 45.4±4.7*,# | 70.3±7.5 |
| HDL, mg/dl | 39.4±6.9 | 39.5±6.7 | 39.1 ±2.4 | 32.3±2 | 42.6±1.8 |
| LDL, mg/dl | 6.1±0.6 | 9.9±0.8 | 27.6±4.5*** | 23.3±1.9*** | 14.8±2.6### |
| Glucose, mg/dl | 231.9±46.8 | 233.4±22.4 | 152.5±15.7* | 208.3±34.8 | 214.3±48.1 |
*,**, ***
- p<0.05, p<0.01, p<0.001 comparison vs si-Control
#, ##, ###
- p<0.05, p<0.01, p<0.001 comparison vs Triple siRNA