Table 3. Stratification analyses between MDM2 SNP309 genotypes and CRC risk.
| Genotypes (cases/controls) | |||||||
|---|---|---|---|---|---|---|---|
| Cases/controls | TT | TG/GG | |||||
| Variables | N | N | % | N | % | TG/GG vs. TT Adjusted OR (95% CI)a | Pa |
| Age (years) | |||||||
| ≤60 | 277/348 | 57/82 | 20.6/23.6 | 220/266 | 79.4/76.4 | 1.15 (0.78–1.70) | 0.468 |
| > 60 | 296/240 | 54/68 | 18.2/28.3 | 242/172 | 81.8/71.7 | 1.76 (1.17–2.64) | 0.007 |
| Sex | |||||||
| Male | 354/367 | 64/93 | 18.1/25.3 | 290/274 | 81.9/74.7 | 1.52 (1.06–2.19) | 0.023 |
| Female | 219/221 | 47/57 | 21.5/25.8 | 172/164 | 78.5/74.2 | 1.28 (0.82–2.01) | 0.274 |
| Smoking status | |||||||
| No | 377/408 | 85/109 | 22.6/26.7 | 292/299 | 77.5/73.3 | 1.28 (0.92–1.79) | 0.141 |
| Yes | 196/180 | 26/41 | 13.3/22.8 | 170/139 | 86.7/77.2 | 1.90 (1.11–3.27) | 0.020 |
| Drinking status | |||||||
| No | 414/451 | 82/118 | 19.8/26.2 | 332/333 | 80.2/73.8 | 1.42 (1.03–1.96) | 0.035 |
| Yes | 159/137 | 29/32 | 18.2/23.4 | 130/105 | 81.8/76.6 | 1.44 (0.81–2.55) | 0.218 |
| Family history of cancer | |||||||
| No | 443/546 | 93/141 | 21.0/25.8 | 350/405 | 79.0/74.2 | 1.33 (0.98–1.80) | 0.063 |
| Yes | 130/42 | 18/9 | 13.9/21.4 | 112/33 | 86.1/78.6 | 1.31 (0.51–3.37) | 0.578 |
aOR (odds ratio), CI (confidence interval), and P values were calculated in dominant model with adjustment for age, sex, smoking status, and alcohol use.