Table 1.
Variables | Hyperthyroidism group | Control groups | F | P | ||||
---|---|---|---|---|---|---|---|---|
TNGT | TIGR | TDM | NGT | IGR | T2DM | |||
n (male/female) | 32 (11/21) | 35 (18/17) | 34 (18/16) | 33 (22/11) | 28 (19/9) | 35 (22/13) | ||
Age (years) | 41.48± 11.71‡,¶ | 48.00± 12.27 | 54.71± 12.71*,§ | 45.26± 15.43‡,¶ | 48.29± 12.98 | 54.31± 12.40*,§ | 4.093 | 0.002 |
BMI (kg/m2) | 22.21± 4.45§,|| | 21.67± 4.83§,|| | 22.79± 5.45§,|| | 26.80± 4.97*,†,‡,¶ | 26.32± 5.05*,†,‡ | 24.31± 3.98§ | 9.416 | 0.000 |
Diabetes duration (months) | 0¶ | 0¶ | 0¶ | 0¶ | 0.27 (0.10± 3.25)¶ | 38.00 (15.00± 61.00)*,†,‡,§,|| | 15.555 | 0.000 |
T3 (nmol/L) | 4.09± 1.88§,||,¶ | 4.04± 1.74§,||,¶ | 3.08± 1.73||,¶ | 2.27± 1.60*,† | 1.93± 1.34*,†,‡ | 1.73± 1.31*,†,‡ | 11.278 | 0.000 |
T4 (nmol/L) | 172.90± 1.94§,||,¶ | 218.59± 1.51§,||,¶ | 156.27± 1.61§,||,¶ | 100.08± 1.85*,†,‡ | 111.81± 1.26*,†,‡ | 114.33± 1.24*,†,‡ | 9.167 | 0.000 |
FT3 (pmol/L) | 12.42± 2.74§,||,¶ | 13.21± 1.97§,||,¶ | 9.33± 2.37§,||,¶ | 5.30± 1.63*,†,‡ | 5.14± 1.53*,†,‡ | 4.43± 1.12*,†,‡ | 12.848 | 0.000 |
FT4 (pmol/L) | 26.25± 3.16§,||,¶ | 33.82± 1.89§,||,¶ | 23.76± 2.78§,||,¶ | 11.34± 1.21*,†,‡ | 12.01± 1.39*,†,‡ | 12.17± 1.17*,†,‡ | 11.028 | 0.000 |
TSH (mU/L) | 0.02 (0.01, 0.07)§,||,¶ | 0.01 (0.01, 004)§,||,¶ | 0.06 (0.01, 0.24)§,||,¶ | 1.97 (1.01, 2.63)*,†,‡ | 1.44 (0.81, 2.51)*,†,‡ | 1.79 (0.94, 2.48)*,†,‡ | 32.067 | 0.000 |
Data are expressed as mean ± standard deviation or median (Q1, Q3). *P<0.05 by one-way ANOVA (vs. TNGT); †P<0.05 by one-way ANOVA (vs. TIGR); ‡P<0.05 by one-way ANOVA (vs. TDM); §P<0.05 by one-way ANOVA (vs. NGT); ||P<0.05 by one-way ANOVA (vs. IGR); ¶P<0.05 by one-way ANOVA (vs. T2DM). TNGT: Hyperthyroidism with normal glucose tolerance; TIGR: Hyperthyroidism with impaired glucose regulation; TDM: Hyperthyroidism with diabetes mellitus; NGT: Normal glucose tolerance control group; IGR: Impaired glucose regulation control group; T2DM: Type 2 diabetes mellitus control group; BMI: Body mass index; T3: Triiodothyronine; T4: Thyroxine; FT3: Free T3; FT4: Free T4; TSH: Thyroid-stimulating hormone; ANOVA: Analysis of variance.