Table 3.
Association of inflammatory dietary pattern score at baseline and cognitive decline over the subsequent 10 years.
| Cognitive change over 10 years, coefficient (95% CI) |
p for interactiona | |||
|---|---|---|---|---|
| Diet pattern score | ||||
| Tertile 1 (low) | Tertile 2 (middle) | Tertile 3 (high) | ||
| Adjusted for demographics | ||||
| Reasoning | −0.31 (−0.34, −0.28) | −0.35 (−0.38, −0.32)* | −0.37 (−0.40,−0.34)** | 0.01 |
| Memory | −0.25 (−0.30, −0.20) | −0.29 (−0.34, −0.24) | −0.30 (−0.35, −0.25) | 0.40 |
| Verbal fluency | −0.38 (−0.42, −0.34) | −0.40 (−0.44, −0.37) | −0.40 (−0.43, −0.36) | 0.68 |
| Global cognition | −0.31 (−0.34, −0.29) | −0.35 (−0.37, −0.32)* | −0.35 (−0.38, −0.33)* | 0.05 |
| Adjusted for demographics and health related factors | ||||
| Reasoning | −0.31 (−0.34, −0.28) | −0.36 (−0.39, −0.33)* | −0.37 (−0.40, −0.33)* | 0.04 |
| Memory | −0.24 (−0.30, −0.19) | −0.28 (−0.33, −0.22) | −0.29 (−0.35, −0.24) | 0.45 |
| Verbal fluency | −0.37 (−0.41, −0.33) | −0.40 (−0.44, −0.36) | −0.40 (−0.44, −0.36) | 0.44 |
| Global cognition | −0.31 (−0.33, −0.28) | −0.35 (−0.37, −0.32)* | −0.35 (−0.38, −0.32)* | 0.04 |
Abbreviation: CI, confidence interval.
NOTE: Estimates derived from linear mixed models using three assessments over 10 years.
Models adjusted for demographics include age, sex, ethnicity, occupational position, education, and total energy intake at baseline.
Health related factors include body mass index, diabetes mellitus, hypertension, smoking history, and leisure time physical activity at baseline.
**p < 0.01, difference in mean cognitive decline compared with referent tertile 1.
*p < 0.05, difference in mean cognitive decline compared with referent tertile 1.
The interaction term tested whether cognitive decline differed across the 3 tertiles of diet pattern score (i.e. low, middle, and high).