Table 3.
Content uniformity of HPMC films with different plasticizers and content. Values are an average of 10 samples ~0.7 cm2 in area.
| Formulation | Thickness (μm) | R.S.D. (%) | Griseofulvin mass per unit area (mg/cm2) | R.S.D. (%) | wt% griseofulvin | R.S.D. (%) |
|---|---|---|---|---|---|---|
| 0.0% plasticizer | 86.9 | 3.9% | 2.48 | 4.2% | 20.9 | 2.3% |
| 2.5% glycerin | 97.1 | 4.8% | 2.57 | 5.8% | 18.2 | 3.5% |
| 5.0% glycerin | 108.0 | 2.9% | 2.16 | 5.5% | 15.3 | 4.2% |
| 2.5% triacetin | 84.4 | 4.4% | 2.05 | 5.4% | 18.7 | 1.0% |
| 5.0% triacetin | 86.6 | 6.5% | 1.99 | 5.9% | 16.4 | 2.3% |
| 2.5% PEG | 72.2 | 2.5% | 1.68 | 1.9% | 16.6 | 2.2% |
| 5.0% PEG | 91.1 | 3.4% | 1.99 | 3.2% | 15.4 | 2.2% |