Figure 3.

Effects of static pressure and pulse pressure on DCFDA-associated H₂O₂ fluorescence (a, c, e) and DAF2-associated NO fluorescence (b, d, f) during flow-mediated dilation in mouse cerebral arteries before or after treatment with PEG-catalase or L-NNA. Typical recordings of fluorescence (arbitrary units, a.u.) are presented (a, b) during dilation induced by flow (20 dyn/cm²), in pressurized (60 mm Hg) pre-constricted cerebral arteries with phenylephrine (PE). Results are mean±SEM of data collected in arterial segments isolated from 14 mice (n numbers indicated for each of the 12 experimental conditions on the graph). *p < 0.05 as indicated.