Figure 1.
Disease-related glucose metabolic patterns. (a) PD-related covariance pattern (PDRP)8,9 was characterized by increased (red) pallidal, thalamic and motor cortical metabolic activities associated with reduced (blue) lateral premotor and parieto-occipital cortical activities. (b) Multiple system atrophy-related covariance pattern (MSARP)10 was characterized by covarying metabolic decreases in the putamen and the cerebellum. (c) Progressive supranuclear palsy-related pattern (PSPRP)10 was characterized by covarying metabolic decreases in the medial prefrontal cortex, frontal eye fields, ventrolateral prefrontal cortex, caudate nuclei, medial thalamus, and upper brainstem. (d) Corticobasal ganglionic degeneration-related pattern (CBDRP)6 was characterized by metabolic reductions in the left frontal and parietal lobes, thalamus and caudate head. Patients' brains that were used to derive CBDRP were flipped left vs. right to align the more affected hemisphere to be on the left. Other disease-related patterns are relatively symmetrical. The voxel-loadings are z-scored.