Table 1.
Summary of hypercapnia and hypoxia induced CBF changes in the literature.
| Hypercapnia | |||||
|---|---|---|---|---|---|
| Study | Condition | Number of subjects | Methods of assessment | Relative CBF change (%) | Cerebrovascular CO2 reactivity (% CBF change/mmHg) |
| Ito et al.35 | 7% CO2 inhalation | 9 | PET | 30.5 | 6 |
| Gauthier et al.36 | 7% CO2 inhalation | 8 | MRI (ASL) | 37.3 | 4.2 |
| Rodgers et al.18 | 5% CO2 inhalation | 10 | MRI (PC-MRI) | 53 | 4.6 |
| Jain et al.37 | 5% CO2 inhalation | 10 | MRI (PC-MRI) | 63 | 7.87 |
| Coverdale et al.38 | 6% CO2 inhalation | 19 | Transcranial Doppler Ultrasound | 50.7 | 5.07 |
| Xu et al.1 | 5% CO2 inhalation | 14 | MRI (PC-MRI) | 54.5 | 6.19 |
| This study |
5% CO2 inhalation | 12 | MRI (PC-MRI) | 44.9 | 5.4 |