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. 2014 Nov 6;4:6881. doi: 10.1038/srep06881

Figure 5. Binding sites of the monoclonal antibodies 1H3, 2G4, and 4G7.

Figure 5

(A) Representation of the position of the escape mutations on the EBOV GP structure (based on PDB# 3CSY) from 5 different angles. The escape mutation to 1H3 (aa 273) is identified in blue. The escape mutation site for 2G4 and 4G7 (aa 508) is identified in red. The monomer where the two amino acids are identified is light gray and the other two monomers are light blue and light orange. The dark gray amino acids (only identified on the light gray monomer) were the amino acids with the top 20% antigenicity score calculated by the Epitopia server. (B) Representation of the position of escape mutations (arrows) and suspected binding sites (lines) on a linear map of GP. The putative binding sites are based on escape mutation data and data from previous publications.