Table 3.

Scope of the Aza-Prins Fluorocyclization^a

entry	R	time (h)	5	yield (%)	cis-5/trans-5b
1	cyclohexyl–	4	5a	100	10:1
2	n-C5H11–	4	5b	100	8.5:1
3	Ph–	24	5c	96	2:1
4	4-Br-C6H4–	24	5d	90	2.5:1
5	4-NO2C6H4–	24	5e	42	2:1
6	4-MeOC6H4–	48	5f	0

^a4 (0.2 mmol), 2 (0.2 mmol), and DMPU/HF (2.1 mmol of HF) in DCE (0.5 mL) was mixed in a polyethylene vial and then stirred at 55 °C.

^bDetermined by ¹⁹F NMR.

^cRoom temperature.

^dDetermined by ¹⁹F NMR using PhCF₃ as internal standard.